Non‑coding RNAs and ovarian diseases (Review)

Mol Med Rep. 2017 Apr;15(4):1435-1440. doi: 10.3892/mmr.2017.6176. Epub 2017 Feb 8.

Abstract

Non-coding RNAs (ncRNAs) are a diverse family of untranslated transcripts, which serve important roles in numerous biological processes. ncRNAs are emerging as major mediators of gene expression with crucial regulatory functions. Ovarian diseases have a wide variety of clinical pathological types, which have serious impacts on women's health. In this review, current studies on ncRNAs are summarized with respect to ovarian diseases. Understanding of the role of ncRNAs in ovarian diseases is currently limited; further studies on the molecular mechanisms by which abnormal expression of ncRNAs contributes to ovarian diseases will aid in the identification of ncRNAs as novel diagnostic markers and therapeutic targets for ovarian diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Carcinogenesis / genetics
  • Female
  • Humans
  • Models, Biological
  • Ovarian Diseases / diagnosis
  • Ovarian Diseases / genetics*
  • Ovary / growth & development
  • Ovary / metabolism
  • RNA, Untranslated / classification
  • RNA, Untranslated / genetics*

Substances

  • RNA, Untranslated