Abstract
Bioactivity-guided fractionation of the ethyl acetate extract obtained from the culture of the endophytic fungus Fusarium solani resulted in the isolation of one new naphthoquinone, 9-desmethylherbarine (1), and two azaanthraquinone derivatives, 7-desmethylscorpinone (2) and 7-desmethyl-6-methylbostrycoidin (3), along with four known compounds. Their structures were elucidated by spectral analysis, as well as a direct comparison of spectral data with those of known compounds. Azaanthraquinones 2 and 3 showed cytotoxic activity against four human tumor cell lines, MDA MB 231, MIA PaCa2, HeLa, and NCI H1975. A molecular docking study suggested DNA interactions as the mode of action of these naphthoquinones and azaanthraquinones.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification*
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Anthraquinones / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology*
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Aza Compounds / chemistry
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Aza Compounds / isolation & purification*
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Aza Compounds / pharmacology*
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Drug Screening Assays, Antitumor
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Fusarium / chemistry*
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HeLa Cells
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Humans
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Molecular Docking Simulation
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Molecular Structure
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Naphthoquinones / chemistry
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Naphthoquinones / isolation & purification*
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Naphthoquinones / pharmacology*
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Acetates
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Anthraquinones
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Antineoplastic Agents
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Aza Compounds
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Naphthoquinones
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ethyl acetate