Traffic from the endosome towards trans-Golgi network

Uma Saimani; Kyoungtae Kim

doi:10.1016/j.ejcb.2017.02.005

Traffic from the endosome towards trans-Golgi network

Eur J Cell Biol. 2017 Mar;96(2):198-205. doi: 10.1016/j.ejcb.2017.02.005. Epub 2017 Feb 24.

Authors

Uma Saimani¹, Kyoungtae Kim²

Affiliations

¹ Department of Biology, Missouri State University, 901 S National, Springfield, MO 65807, United States.
² Department of Biology, Missouri State University, 901 S National, Springfield, MO 65807, United States. Electronic address: kkim@missouristate.edu.

PMID: 28256269
DOI: 10.1016/j.ejcb.2017.02.005

Abstract

Retrograde passage of a transport carrier entails cargo sorting at the endosome, generation of a cargo-laden carrier and its movement along cytoskeletal tracks towards trans-Golgi network (TGN), tethering at the TGN, and fusion with the Golgi membrane. Significant advances have been made in understanding this traffic system, revealing molecular requirements in each step and the functional connection between them as well as biomedical implication of the dysregulation of those important traffic factors. This review focuses on describing up-to-date action mechanisms for retrograde transport from the endosomal system to the TGN.

Keywords: Endosome; Retrograde transport; SNAREs; Sorting; Tether; Trans-Golgi network.

Publication types

Review

MeSH terms

Endosomes / metabolism*
Humans
trans-Golgi Network / metabolism*