Personalized plasma-based medicine to treat age-related diseases

Mater Sci Eng C Mater Biol Appl. 2017 May 1:74:459-464. doi: 10.1016/j.msec.2016.12.040. Epub 2016 Dec 13.

Abstract

As social and health needs are changing, new challenges to develop innovative alternatives arise to address unmet medical needs. Personalized medicine is emerging as a promising and appealing therapeutic option. The use of patient's own plasma and platelets as therapeutics is providing new avenues in the treatment of acute and chronic tissue injuries by promoting tissue repair and regeneration. Plasma and platelet-based therapies mimic the physiological repair process by releasing autologous growth factors and creating a natural, biodegradable and transient scaffold that acts as transient matrix. This review summarizes the recent advances and challenges in the field of personalized plasma-based medicine and its potential to treat age-related diseases.

Keywords: Autologous therapies; Growth factors; Personalized medicine; Platelet rich plasma; Scaffold; Tissue regeneration.

Publication types

  • Review

MeSH terms

  • Dry Eye Syndromes / pathology
  • Dry Eye Syndromes / therapy
  • Fibrin / chemistry
  • Fibrin / metabolism
  • Humans
  • Intercellular Signaling Peptides and Proteins / chemistry
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Platelet-Rich Plasma / chemistry*
  • Platelet-Rich Plasma / metabolism
  • Precision Medicine*
  • Regeneration / physiology
  • Temporomandibular Joint Disorders / pathology
  • Temporomandibular Joint Disorders / therapy
  • Tendinopathy / pathology
  • Tendinopathy / therapy
  • Transplantation, Autologous

Substances

  • Intercellular Signaling Peptides and Proteins
  • Fibrin