Abstract
Phytochemistry investigation on Pteris ensiformis led to the isolation of a new ent-kaurane diterpenoid, ent-kaurane-6β,16α-diol-3-one (1), along with five known diterpenoids (2-6) and three known sesquiterpenes (7-9). Their structures were established by means of spectroscopic methods. The ethanol extract and the isolated compounds (1-9) were evaluated for their antitumor activity against three cancer cell lines.
Keywords:
16α-diol-3-one; Pteridaceae; Pteris ensiformi; cytotoxicity; ent-kaurane diterpenoid; ent-kaurane-6β.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Diterpenes, Kaurane / chemistry
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Diterpenes, Kaurane / isolation & purification*
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Diterpenes, Kaurane / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pteris / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Diterpenes, Kaurane
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ent-kaurane-6beta,16alpha-diol-3-one