The influence of sarcopenia in dropped head syndrome in older women

Yawara Eguchi; Toru Toyoguchi; Masao Koda; Munetaka Suzuki; Hajime Yamanaka; Hiroshi Tamai; Tatsuya Kobayashi; Sumihisa Orita; Kazuyo Yamauchi; Miyako Suzuki; Kazuhide Inage; Kazuki Fujimoto; Hirohito Kanamoto; Koki Abe; Yasuchika Aoki; Kazuhisa Takahashi; Seiji Ohtori

doi:10.1186/s13013-017-0110-6

The influence of sarcopenia in dropped head syndrome in older women

Scoliosis Spinal Disord. 2017 Feb 22:12:5. doi: 10.1186/s13013-017-0110-6. eCollection 2017.

Authors

Yawara Eguchi¹, Toru Toyoguchi², Masao Koda³, Munetaka Suzuki¹, Hajime Yamanaka¹, Hiroshi Tamai¹, Tatsuya Kobayashi¹, Sumihisa Orita³, Kazuyo Yamauchi³, Miyako Suzuki³, Kazuhide Inage³, Kazuki Fujimoto³, Hirohito Kanamoto³, Koki Abe³, Yasuchika Aoki⁴, Kazuhisa Takahashi³, Seiji Ohtori³

Affiliations

¹ Department of Orthopeadic Surgery, Shimoshizu National Hospital, 934-5, Shikawatashi, Yotsukaido, Chiba 284-0003 Japan.
² Department of Orthopaedic Surgery, Chiba Qiball Clinic, 4-5-1, Chuo-ku, Chiba, 260-0013 Japan.
³ Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670 Japan.
⁴ Department of Orthopaedic Surgery, Eastern Chiba Medical Center, 3-6-2, Okayamadai, Togane, Chiba 283-8686 Japan.

Abstract

Background: Age-related sarcopenia may cause physical dysfunction. We investigated the involvement of sarcopenia in dropped head syndrome (DHS).

Methods: Our study subjects were ten elderly women with idiopathic DHS (mean age 75.1 years, range 55-89). Twenty age- and sex-matched volunteers (mean age 73.0, range 58-83) served as controls. We used a bioelectrical impedance analyzer (BIA) to analyze body composition, including appendicular skeletal muscle mass index (SMI; appendicular lean mass (kg)/(height (m))²). SMI <5.75 was considered diagnostic for sarcopenia. Cervical sagittal plane alignment: C2-7 sagittal vertical axis (SVA), C2-7 angle (C2-C7 A), and C2 slope (C2S) were also measured. We investigated sarcopenia prevalence in both groups, height, weight, BMI, lean mass arm, lean mass leg, lean mass trunk, appendicular lean mass, total lean mass, and SMI. In addition, we also examined the correlation between cervical spine alignment and SMI in DHS.

Results: Sarcopenia was observed at a high rate in DHS subjects: 70% compared to 25% of healthy controls. Height, weight, BMI, lean mass arm, lean mass leg, axial lean mass, appendicular lean mass, total lean mass, and SMI all had significantly lower values in the DHS group. In particular, total lean mass, lean mass arm, and lean mass trunk were considerably lower in the DHS group. There was no correlation noted between cervical spine alignment and SMI.

Conclusions: Sarcopenia prevalence was high in the DHS group-70 versus 25% in the control group, suggesting the involvement of sarcopenia in DHS. In particular, axial lean mass and lean mass arm were markedly reduced in the DHS group. DHS is due to significant weakness of the neck extensor group, and chin-on-chest deformity occurs. Until the present, evaluation of DHS has been done using only MRI; no studies have systematically examined skeletal muscle mass. In the present study, muscle mass decrease was noted not only in the neck muscles but also throughout the entire body. Involvement of trunk and upper limb muscles in particular suggests a disuse atrophy of the upper body and spinal muscles. BIA can easily and systemically evaluate skeletal muscle mass. We expect it to contribute to further elucidating the pathogenesis of DHS.

Keywords: Bioelectrical impedance analyzer; Dropped head syndrome; Sarcopenia; Skeletal muscle.