Frequent involvement of the fim-3 region in Friend murine leukemia virus-induced mouse myeloblastic leukemias

D Bordereaux; S Fichelson; B Sola; P E Tambourin; S Gisselbrecht

doi:10.1128/JVI.61.12.4043-4045.1987

Frequent involvement of the fim-3 region in Friend murine leukemia virus-induced mouse myeloblastic leukemias

J Virol. 1987 Dec;61(12):4043-5. doi: 10.1128/JVI.61.12.4043-4045.1987.

Authors

D Bordereaux¹, S Fichelson, B Sola, P E Tambourin, S Gisselbrecht

Affiliation

¹ Laboratoire Immunologie et Virologie des Tumeurs, Institut National de la Santé et de la Recherche Médicale, Paris, France.

Abstract

fim-3 is a new proviral integration region involved in 23% (16 of 68) of Friend murine leukemia virus-induced myeloblastic leukemias. This region is distinct from 20 oncogenes and from putative oncogenes tested so far. Proviruses are integrated in a 16-kilobase region, always in the same orientation. No RNA expression of fim-3 was detected.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line
DNA Restriction Enzymes
DNA, Viral / genetics
Friend murine leukemia virus / genetics*
Genes, Viral*
Leukemia, Experimental / microbiology*
Leukemia, Myeloid, Acute / microbiology
Nucleic Acid Hybridization
Oncogenes*
Proviruses / genetics*

Substances

DNA, Viral
DNA Restriction Enzymes