Triple-reassortant influenza A virus with H3 of human seasonal origin, NA of swine origin, and internal A(H1N1) pandemic 2009 genes is established in Danish pigs

Influenza Other Respir Viruses. 2017 May;11(3):298-303. doi: 10.1111/irv.12451. Epub 2017 Mar 21.

Abstract

This report describes a triple-reassortant influenza A virus with a HA that resembles H3 of human seasonal influenza from 2004 to 2005, N2 from influenza A virus already established in swine, and the internal gene cassette from A(H1N1)pdm09 has spread in Danish pig herds. The virus has been detected in several Danish pig herds during the last 2-3 years and may possess a challenge for human as well as animal health.

Keywords: H1N1pdm09; H3N2; case report; influenza A virus; zoonosis.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Denmark
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics*
  • Hemagglutinin Glycoproteins, Influenza Virus / metabolism
  • Humans
  • Influenza A Virus, H1N1 Subtype / classification
  • Influenza A Virus, H1N1 Subtype / genetics*
  • Influenza A Virus, H1N1 Subtype / metabolism
  • Influenza A virus / classification
  • Influenza A virus / genetics*
  • Influenza A virus / metabolism
  • Influenza, Human / virology*
  • Neuraminidase / genetics*
  • Neuraminidase / metabolism
  • Orthomyxoviridae Infections / veterinary*
  • Orthomyxoviridae Infections / virology
  • Phylogeny
  • Reassortant Viruses / classification
  • Reassortant Viruses / genetics*
  • Reassortant Viruses / immunology
  • Reassortant Viruses / metabolism
  • Recombination, Genetic
  • Seasons
  • Swine
  • Swine Diseases / virology*
  • Viral Proteins / genetics*
  • Viral Proteins / metabolism

Substances

  • Hemagglutinin Glycoproteins, Influenza Virus
  • Viral Proteins
  • NA protein, influenza A virus
  • Neuraminidase