A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy

Chem Commun (Camb). 2017 Mar 9;53(21):3126-3129. doi: 10.1039/c7cc00950j.

Abstract

A mitochondria-targeting supramolecular photosensitizer system TPP-QAS/WP5/DTAB was constructed based on a host-guest inclusion complex. The supramolecular system could efficiently release and activate TPP-QASs in an acidic environment, which have been demonstrated to preferentially accumulate in mitochondria. Singlet oxygen (1O2) could be in situ generated in mitochondria under light irradiation, further enhancing the PDT efficacy.

MeSH terms

  • Calixarenes
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Humans
  • Macromolecular Substances / chemistry
  • Macromolecular Substances / metabolism
  • Macromolecular Substances / pharmacokinetics
  • Macromolecular Substances / pharmacology
  • Microscopy, Confocal
  • Mitochondria / drug effects*
  • Mitochondria / metabolism*
  • Molecular Structure
  • Photochemotherapy*
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / metabolism*
  • Photosensitizing Agents / pharmacokinetics
  • Photosensitizing Agents / pharmacology
  • Quaternary Ammonium Compounds / chemistry
  • Quaternary Ammonium Compounds / metabolism*
  • Quaternary Ammonium Compounds / pharmacokinetics
  • Quaternary Ammonium Compounds / pharmacology
  • Structure-Activity Relationship

Substances

  • Macromolecular Substances
  • Photosensitizing Agents
  • Quaternary Ammonium Compounds
  • pillar(5)arene
  • Calixarenes