The discovery of fluazaindolizine: A new product for the control of plant parasitic nematodes

Bioorg Med Chem Lett. 2017 Apr 1;27(7):1572-1575. doi: 10.1016/j.bmcl.2017.02.029. Epub 2017 Feb 16.

Abstract

Fluazaindolizine is a new highly effective and selective product for the control of plant parasitic nematodes. Specificity for nematodes coupled with absence of activity against the target sites of commercial nematicides suggests that fluazaindolizine has a novel mode of action. The discovery, structure-activity development and biological properties for this new class of nematicides are presented.

Keywords: Fluazaindolizine; Nematicide; Plant parasitic nematodes; Structure-activity relationships.

MeSH terms

  • Animals
  • Caenorhabditis elegans / drug effects
  • Crops, Agricultural / parasitology
  • Drosophila melanogaster / drug effects
  • Heterocyclic Compounds, 2-Ring / chemical synthesis
  • Heterocyclic Compounds, 2-Ring / pharmacology*
  • Heterocyclic Compounds, 2-Ring / toxicity
  • Indolizines / chemical synthesis
  • Indolizines / pharmacology*
  • Indolizines / toxicity
  • Pesticides / chemical synthesis
  • Pesticides / pharmacology*
  • Pesticides / toxicity
  • Plant Roots / parasitology
  • Structure-Activity Relationship
  • Sulfonamides / chemical synthesis
  • Sulfonamides / pharmacology*
  • Sulfonamides / toxicity
  • Tylenchoidea / drug effects

Substances

  • Heterocyclic Compounds, 2-Ring
  • Indolizines
  • Pesticides
  • Sulfonamides
  • fluazaindolizine