Correlations between lncRNA-SOX2OT polymorphism and susceptibility to breast cancer in a Chinese population

Biomark Med. 2017 Mar;11(3):277-284. doi: 10.2217/bmm-2016-0238. Epub 2017 Feb 17.

Abstract

Aim: We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study.

Methods: A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues' SOX2OT expression. Genotyping of rs9839776 were conducted by using SNaPshot assays.

Results: SOX2OT were overexpressed in BC tissues (p < 0.001). SOX2OT SNP rs9839776 was strongly associated with the higher expression of SOX2OT and an increased risk of BC in Chinese women (odds ratio: 1.42; 95% CI: 1.06-1.90; p = 0.018).

Conclusion: These results confirmed that BC was conspicuously associated with higher SOX2OT expression. SOX2OT SNP rs9839776 was significantly associated with the onset of BC possibly via influencing the expression of SOX2OT.

Keywords: SOX2OT; breast cancer; long noncoding RNA; polymorphism.

MeSH terms

  • Aged
  • Alleles
  • Asian People / genetics*
  • Breast / metabolism
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism
  • Case-Control Studies
  • China
  • Disease Susceptibility
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Single Nucleotide
  • RNA, Long Noncoding / genetics*
  • Risk

Substances

  • RNA, Long Noncoding
  • long non-coding RNA Sox2ot, human