Genomic analysis of a Streptococcus pyogenes strain causing endocarditis in a child

M Beye; K El Karkouri; N Labas; D Raoult; P-E Fournier

doi:10.1016/j.nmni.2017.01.007

Genomic analysis of a Streptococcus pyogenes strain causing endocarditis in a child

New Microbes New Infect. 2017 Jan 28:17:1-6. doi: 10.1016/j.nmni.2017.01.007. eCollection 2017 May.

Authors

M Beye¹, K El Karkouri¹, N Labas¹, D Raoult², P-E Fournier¹

Affiliations

¹ URMITE, UM63, CNRS7278, IRD198, Inserm1095, Institut Hospitalo-Universitaire Méditerranée-infection, Aix-Marseille Université, Faculté de Médecine, Marseille, France.
² URMITE, UM63, CNRS7278, IRD198, Inserm1095, Institut Hospitalo-Universitaire Méditerranée-infection, Aix-Marseille Université, Faculté de Médecine, Marseille, France; Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdul Aziz University, Jeddah, Saudi Arabia.

Abstract

We sequenced the genome of Streptococcus pyogenes strain G773 that caused an infective endocarditis in a 4-year-old boy suffering from acute endocarditis. The 1.9-Mb genome exhibited a specific combination of virulence factors including a complete integrative and conjugative element, sp2905, previously described as incomplete in S. pyogenes, and five bacteriocin-coding genes. However, strain G773 lacked a CRISPR-Cas system.

Keywords: Endocarditis; Streptococcus pyogenes; genome comparison; real-time genome sequencing; virulence.