Synthesis of sandwich-like molybdenum sulfide/mesoporous organosilica nanosheets for photo-thermal conversion and stimuli-responsive drug release

J Colloid Interface Sci. 2017 Jun 15:496:261-266. doi: 10.1016/j.jcis.2017.01.068. Epub 2017 Jan 21.

Abstract

Sandwich-like molybdenum sulfide/mesoporous organosilica nanosheets (denoted as MoS2@MOS) have been prepared for the first time via direct growth of ethane-bridged mesostructured organosilica on MoS2 nanosheets by using cetyltrimethylammonium bromide (CTAB) as structure directing agent. The obtained MoS2@MOS nanosheets possess well-defined sandwich-like structure, high surface area (∼920cm2/g), uniform pore size (∼4.2nm), large pore volume (∼1.41cm3g-1). In vitro cytotoxicity assessments demonstrate that the MoS2@MOS nanosheets have excellent biocompatibility. Owing to the encapsulation of the MoS2, the obtained MoS2@MOS nanosheets have photo-thermal conversion capability and photo-thermally controlled drug release property. These properties make the MoS2@MOS nanosheets promising for biomedical applications.

Keywords: Drug release; Mesoporous organosilica; MoS(2); Photo-thermal conversion; Sandwich structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Biocompatible Materials / chemistry
  • Cell Survival / drug effects
  • Cetrimonium
  • Cetrimonium Compounds / chemistry
  • Disulfides / chemistry*
  • Disulfides / toxicity
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology
  • Drug Delivery Systems
  • Drug Liberation
  • Hot Temperature
  • Humans
  • Lasers
  • MCF-7 Cells
  • Molybdenum / chemistry*
  • Molybdenum / toxicity
  • Nanostructures / chemistry*
  • Nanostructures / radiation effects
  • Nanostructures / toxicity
  • Organosilicon Compounds / chemistry*
  • Organosilicon Compounds / toxicity
  • Particle Size
  • Porosity
  • Surface Properties

Substances

  • Antineoplastic Agents
  • Biocompatible Materials
  • Cetrimonium Compounds
  • Disulfides
  • Organosilicon Compounds
  • Doxorubicin
  • Molybdenum
  • Cetrimonium
  • molybdenum disulfide