Diminished protein-bound ω-hydroxylated ceramides in the skin of patients with ichthyosis with 12R-lipoxygenase (LOX) or eLOX-3 deficiency

Br J Dermatol. 2017 Oct;177(4):e119-e121. doi: 10.1111/bjd.15406. Epub 2017 Aug 28.
No abstract available

Publication types

  • Letter
  • Multicenter Study

MeSH terms

  • Arachidonate 12-Lipoxygenase / deficiency*
  • Arachidonate 12-Lipoxygenase / genetics
  • Arachidonate 5-Lipoxygenase / genetics
  • Case-Control Studies
  • Ceramides / metabolism*
  • Child
  • Homozygote
  • Humans
  • Ichthyosis / metabolism*
  • Lipoxygenase / deficiency*
  • Mutation / genetics
  • Skin / chemistry*

Substances

  • Ceramides
  • ALOXE3 protein, human
  • Lipoxygenase
  • ALOX12B protein, human
  • Arachidonate 12-Lipoxygenase
  • Arachidonate 5-Lipoxygenase
  • ALOX5 protein, human