Mimicking Horseradish Peroxidase Functions Using Cu2+-Modified Carbon Nitride Nanoparticles or Cu2+-Modified Carbon Dots as Heterogeneous Catalysts

Margarita Vázquez-González; Wei-Ching Liao; Rémi Cazelles; Shan Wang; Xu Yu; Vitaly Gutkin; Itamar Willner

doi:10.1021/acsnano.7b00352

Mimicking Horseradish Peroxidase Functions Using Cu²⁺-Modified Carbon Nitride Nanoparticles or Cu²⁺-Modified Carbon Dots as Heterogeneous Catalysts

ACS Nano. 2017 Mar 28;11(3):3247-3253. doi: 10.1021/acsnano.7b00352. Epub 2017 Mar 3.

Authors

Margarita Vázquez-González¹, Wei-Ching Liao¹, Rémi Cazelles¹, Shan Wang¹, Xu Yu¹, Vitaly Gutkin¹, Itamar Willner¹

Affiliation

¹ Institute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.

PMID: 28234445
DOI: 10.1021/acsnano.7b00352

Abstract

Cu²⁺-functionalized carbon nitride nanoparticles (Cu²⁺-g-C₃N₄ NPs), ∼200 nm, and Cu²⁺-carbon dots (Cu²⁺-C-dots), ∼8 nm, act as horseradish peroxidase-mimicking catalysts. The nanoparticles catalyze the generation of chemiluminescence in the presence of luminol/H₂O₂ and catalyze the oxidation of dopamine by H₂O₂ to form aminochrome. The Cu²⁺-g-C₃N₄-driven generation of chemiluminescence is used to develop a H₂O₂ sensor and is implemented to develop a glucose detection platform and a sensor for probing glucose oxidase. Also, the Cu²⁺-C-dots are functionalized with the β-cyclodextrin (β-CD) receptor units. The concentration of dopamine, at the Cu²⁺-C-dots' surface, by means of the β-CD receptor sites, leads to a 4-fold enhancement in the oxidation of dopamine by H₂O₂ to yield aminochrome compared to that of the unmodified C-dots.

Keywords: chemiluminescence; cyclodextrin; dopamine; glucose; sensor.

Publication types

Research Support, Non-U.S. Gov't