Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?

Neurosci Lett. 2017 Mar 22:644:1-4. doi: 10.1016/j.neulet.2017.02.043. Epub 2017 Feb 21.

Abstract

Role of lithium chloride and paraldehyde in acute changes after lithium-pilocarpine status epilepticus (SE) induced at postnatal day 12 was studied in 15-day-old rats. In addition to SE group four other groups were formed: naïve animals without any injection, lithium chloride group, paraldehyde group and lithium-paraldehyde group. Cortical epileptic afterdischarges (CxADs) induced by increasing intensities of stimulation current were used as a measure of excitability. SE animals did not exhibit any change in duration of CxADs with increasing stimulation intensity in contrast to naïve control with a progressive prolongation of CxAD. LiCl group was similar to SE rats whereas paraldehyde and lithium-paraldehyde groups exhibited some progress in duration of ADs. Lithium chloride participates in short-term changes of CxADs after SE. Paraldehyde and combination of lithium and paraldehyde are similar to naïve controls.

Keywords: Cortical epileptic afterdischarges; Immature rats; Lithium chloride; Paraldehyde; Pilocarpine; Status epilepticus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticonvulsants / pharmacology*
  • Cerebral Cortex / drug effects
  • Convulsants / pharmacology*
  • Disease Models, Animal
  • Lithium Chloride / pharmacology*
  • Male
  • Paraldehyde / pharmacology*
  • Pilocarpine / pharmacology*
  • Rats
  • Rats, Wistar
  • Status Epilepticus / chemically induced*

Substances

  • Anticonvulsants
  • Convulsants
  • Pilocarpine
  • Lithium Chloride
  • Paraldehyde