Quantitative cognitive-test characterization of reconnectable implantable fiber-optic neurointerfaces for optogenetic neurostimulation

I V Fedotov; O I Ivashkina; M S Pochechuev; M A Roshchina; K A Toropova; A B Fedotov; K V Anokhin; A M Zheltikov

doi:10.1002/jbio.201600225

Quantitative cognitive-test characterization of reconnectable implantable fiber-optic neurointerfaces for optogenetic neurostimulation

J Biophotonics. 2017 Nov;10(11):1485-1491. doi: 10.1002/jbio.201600225. Epub 2017 Feb 23.

Authors

I V Fedotov^{1

2

3}, O I Ivashkina^{3

4}, M S Pochechuev^{3

4}, M A Roshchina^{3

4}, K A Toropova^{3

4}, A B Fedotov^{1

3}, K V Anokhin⁴, A M Zheltikov^{1

2

3

4}

Affiliations

¹ Physics Department, International Laser Center, M. V. Lomonosov Moscow State University, Moscow, 119992, Russia.
² Department of Physics and Astronomy, Texas A&M University, College Station, TX, 77843, USA.
³ Russian Quantum Center, ul. Novaya 100, Skolkovo, Moscow Region, 143025, Russia.
⁴ Kurchatov Institute National Research Center, pl. akad. Kurchatova 1, Moscow, 123182, Russia.

PMID: 28230316
DOI: 10.1002/jbio.201600225

Abstract

Cognitive tests on representative groups of freely behaving transgenic mice are shown to enable a quantitative characterization of reconnectable implantable fiber-optic neurointerfaces for optogenetic neurostimulation. A systematic analysis of such tests provides a robust quantitative measure for the cognitive effects induced by fiber-optic neurostimulation, validating the performance of fiber-optic neurointerfaces for long-term optogenetic brain stimulations and showing no statistically significant artifacts in the behavior of transgenic mice due to interface implantation.

Keywords: Neurophotonics; fiber-optic neurointerfaces.

MeSH terms

Animals
Brain / physiology
Cognition*
Implantable Neurostimulators*
Mice
Mice, Transgenic
Optical Fibers*
Optogenetics / instrumentation*
Prostheses and Implants*