Right upper quadrant abdominal pain as the initial presentation of polyarteritis nodosa

BMJ Case Rep. 2017 Feb 22:2017:bcr2016218019. doi: 10.1136/bcr-2016-218019.

Abstract

Polyarteritis nodosa (PAN) is a necrotising vasculitis that involves medium and small vessels. PAN generally presents with constitutional, cutaneous, neurological, renal and gastrointestinal manifestations. However, PAN initially involving a single organ/system is uncommon. Here, we present a 42-year-old man who was hospitalised because of severe right upper quadrant abdominal pain that started 2 months before. Physical examination was remarkable for right upper quadrant abdominal tenderness. Abdominopelvic CT showed lymphadenopathy but no hepatic, gallbladder, pancreatic, intestinal or renal abnormalities. Abdominal angiography showed multiple small aneurysms located in the jejunal and hepatic arteries characteristic of PAN. He had a prompt and remarkable response to high-dose corticosteroids and oral cyclophosphamide. Our case, together with other reports, suggests that PAN should be considered in patients presenting with right upper abdominal pain. Timely diagnosis and treatment reduce the overall morbidity and mortality of the disease.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Pain / etiology*
  • Adult
  • Angiography
  • Anti-Inflammatory Agents / therapeutic use
  • Cyclophosphamide / therapeutic use
  • Hepatic Artery* / diagnostic imaging
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Methylprednisolone / therapeutic use
  • Polyarteritis Nodosa / complications*
  • Polyarteritis Nodosa / diagnostic imaging
  • Polyarteritis Nodosa / drug therapy
  • Tomography, X-Ray Computed

Substances

  • Anti-Inflammatory Agents
  • Immunosuppressive Agents
  • Cyclophosphamide
  • Methylprednisolone