Effect of Helicobacter pylori on metabolic syndrome parameters in diabetic patients

Jamshid Vafaeimanesh; Mohammad Bagherzadeh; Atefeh Mirzaei; Mahmoud Parham; Mohsen Norouzinia; Reza Vafaee

Effect of Helicobacter pylori on metabolic syndrome parameters in diabetic patients

Gastroenterol Hepatol Bed Bench. 2016 Dec;9(Suppl1):S36-S41.

Authors

Jamshid Vafaeimanesh¹, Mohammad Bagherzadeh², Atefeh Mirzaei³, Mahmoud Parham⁴, Mohsen Norouzinia⁵, Reza Vafaee⁶

Affiliations

¹ Gastrointestinal and Liver Disease Research Center, Iran University of Medical Science, Tehran, Iran; Qom Gastroenterology and Hepatlogy Research Center, Qom University of Medical Sciences, Qom, Iran.
² Qom Gastroenterology and Hepatlogy Research Center, Qom University of Medical Sciences, Qom, Iran.
³ General Proctitioner, Qom University of Medical Sciences, Qom, Iran.
⁴ Endocrinologist, Qom Gastroenterology and Hepatlogy Research Center, Qom University of Medical Sciences, Qom, Iran.
⁵ Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁶ Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Safety Promotion and Injury Prevention Research Center, Shahid Beheshti University of medical sciences, Tehran, Iran.

PMID: 28224026
PMCID: PMC5310798

Abstract

Aim: The aim of this study is to survey the effect of Helicobacter Pylori on metabolic syndrome parameters in diabetic patients.

Background: Helicobacter pylori (HP) infection is the most common infection in developing countries. Some studies showed the association between HP infection and insulin resistance. Insulin resistance is a major mechanism in the development of metabolic syndrome (MetS) and it is said that MetS is more prevalent among HP infected subjects. Also, some studies have shown that MetS is common among patients with type 2 diabetes mellitus. In this study, we aimed to investigate the prevalence of MetS in diabetic patients and its association with HP.

Methods: This cross-sectional study was carried out from May to December 2014 on 211 diabetic patients. For each patient, the following data were collected: age, gender, diabetes duration, weight, body mass index (BMI), waist circumference, blood pressure (BP), HDL, cholesterol, triglyceride (TG), total cholesterol, and HbA1c. The lipid profile was performed on fasting samples. Anti- HP IgG antibody was measured and serum titer >30AU/mL was considered positive. MetS was diagnosed by The National Cholesterol Education Program's Adult Treatment Panel III report (NCEP-ATPIII) and IDF criteria.

Results: Totally 139 patients (65.9%) were HP+ and 72 patients (34.1%) were HP-. Age, gender and diabetes duration were not significantly different in both groups. BMI was significantly lower in HP+ women (29.05±5.26 vs. 31.45±4.8, p=0.02). Although the waist circumference of men was not different between the two groups but it was significantly lower in HP+ women (102.04±12.37 vs. 97.3±10, p=0.03). Although BP and TG levels were not statistically different in HP+ and HP- patients, but HP+ patients had lower HDL level (p=0.037) which was due to lower HDL in men (58.2±26.6 vs. 72.48±28.1, p=0.012). The prevalence of MetS according to the IDF criteria among HP+ and HP- patients was 76.6% vs. 69.8% (p=0.27). Also, the prevalence of MetS according to NCEP-ATP III criteria among HP+ and HP- patients was 90.4% vs. 87.2% (p=0.5). Duration of diabetes did not affect the prevalence of metabolic syndrome among HP+ and HP- patients.

Conclusion: It seems that HP infection increases the prevalence of metabolic syndrome through an increase in insulin resistance. According to NCEP-ATPIII criteria, the increase in the prevalence of metabolic syndrome in HP+ patients is almost significant, however more complete studies is recommended to investigate this relationship.

Keywords: Diabetes; Helicobacter pylori; metabolic syndrome.