Briarane Diterpenoids Isolated from Octocorals between 2014 and 2016

Yin-Di Su; Jui-Hsin Su; Tsong-Long Hwang; Zhi-Hong Wen; Jyh-Horng Sheu; Yang-Chang Wu; Ping-Jyun Sung

doi:10.3390/md15020044

Briarane Diterpenoids Isolated from Octocorals between 2014 and 2016

Mar Drugs. 2017 Feb 17;15(2):44. doi: 10.3390/md15020044.

Authors

Yin-Di Su¹, Jui-Hsin Su^{2

3}, Tsong-Long Hwang⁴, Zhi-Hong Wen⁵, Jyh-Horng Sheu⁶, Yang-Chang Wu^{7

8

9}, Ping-Jyun Sung^{10

11

12

13

14}

Affiliations

¹ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. gobetter04@gmail.com.
² National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. x2219@nmmba.gov.tw.
³ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. x2219@nmmba.gov.tw.
⁴ Graduate Institute of Natural Products, College of Medicine, Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁵ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
⁶ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.
⁷ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@kmu.edu.tw.
⁸ Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@kmu.edu.tw.
⁹ Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. yachwu@kmu.edu.tw.
¹⁰ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹¹ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹² Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.
¹³ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.
¹⁴ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.

Abstract

The structures, names, bioactivities, and references of 124 briarane-type natural products, including 66 new metabolites, isolated between 2014 and 2016 are summarized in this review article. All of the briarane diterpenoids mentioned in this review were isolated from octocorals, mainly from Briareum violacea, Dichotella gemmacea, Ellisella dollfusi, Junceella fragilis, Junceella gemmacea, and Pennatula aculeata. Some of these compounds exhibited potential biomedical activities, including anti-inflammatory activity, antibacterial activity, and cytotoxicity towards cancer cells.

Keywords: Briareum; Dichotella; Ellisella; Junceella; Pennatula; briarane; octocoral.

Publication types

Review

MeSH terms

Animals
Anthozoa / chemistry*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology*
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology*
Antibiotics, Antineoplastic / chemistry
Antibiotics, Antineoplastic / isolation & purification
Antibiotics, Antineoplastic / pharmacology*
Biological Products / chemistry
Biological Products / isolation & purification
Biological Products / pharmacology*
Cell Line, Tumor
Diterpenes / chemistry
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Humans
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy

Substances

Anti-Bacterial Agents
Anti-Inflammatory Agents
Antibiotics, Antineoplastic
Biological Products
Diterpenes