Abstract
Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides still remains a challenge. Here we describe a straightforward method for the click functionalization of siRNAs with peptides of different sizes and complexities. Among them, a promising peptide carrier for the selective siRNA delivery into HER2+ breast cancer cell lines has been reported.
MeSH terms
-
Breast Neoplasms / genetics
-
Breast Neoplasms / metabolism*
-
Breast Neoplasms / pathology
-
Cell Line, Tumor
-
Click Chemistry
-
Drug Carriers / chemistry
-
Drug Carriers / pharmacokinetics
-
Female
-
Humans
-
Molecular Conformation
-
Peptides / chemistry*
-
Peptides / pharmacokinetics*
-
RNA, Small Interfering / chemistry*
-
RNA, Small Interfering / pharmacokinetics*
-
Receptor, ErbB-2 / genetics
Substances
-
Drug Carriers
-
Peptides
-
RNA, Small Interfering
-
ERBB2 protein, human
-
Receptor, ErbB-2