Occurrence of Crohn's disease with Parkinson's disease

Parkinsonism Relat Disord. 2017 Apr:37:116-117. doi: 10.1016/j.parkreldis.2017.01.013. Epub 2017 Feb 10.

Abstract

We retrospectively investigated the co-occurrence of Crohn's disease in a cohort of 876 patients with Parkinson's disease, based on the observation that LRRK2 is a shared genetic risk factor. We identified 2 patients with Crohn's disease; this number was consistent with the number of cases expected in the general population.

Keywords: Co-occurrence; Crohn's disease; LRRK2; Parkinson’s disease.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Crohn Disease / epidemiology*
  • Crohn Disease / genetics
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / genetics
  • Male
  • Middle Aged
  • Mutation / genetics
  • Parkinson Disease / epidemiology*
  • Parkinson Disease / genetics
  • Retrospective Studies

Substances

  • LRRK2 protein, human
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2