ProBiS tools (algorithm, database, and web servers) for predicting and modeling of biologically interesting proteins

Janez Konc; Dušanka Janežič

doi:10.1016/j.pbiomolbio.2017.02.005

ProBiS tools (algorithm, database, and web servers) for predicting and modeling of biologically interesting proteins

Prog Biophys Mol Biol. 2017 Sep:128:24-32. doi: 10.1016/j.pbiomolbio.2017.02.005. Epub 2017 Feb 15.

Authors

Janez Konc¹, Dušanka Janežič²

Affiliations

¹ National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia; Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Glagoljaška 8, SI-6000, Koper, Slovenia.
² Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Glagoljaška 8, SI-6000, Koper, Slovenia. Electronic address: dusanka.janezic@upr.si.

PMID: 28212856
DOI: 10.1016/j.pbiomolbio.2017.02.005

Abstract

ProBiS (Protein Binding Sites) Tools consist of algorithm, database, and web servers for prediction of binding sites and protein ligands based on the detection of structurally similar binding sites in the Protein Data Bank. In this article, we review the operations that ProBiS Tools perform, provide comments on the evolution of the tools, and give some implementation details. We review some of its applications to biologically interesting proteins. ProBiS Tools are freely available at http://probis.cmm.ki.si and http://probis.nih.gov.

Keywords: Binding sites; Prediction; ProBiS; Protein structure; Structural similarity.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Algorithms*
Computational Biology / methods*
Databases, Protein*
Humans
Internet*
Models, Molecular*
Proteins* / chemistry
Proteins* / metabolism

Substances

Proteins