Abstract
Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+ T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 supratype. We here disclose a novel signature associated with the Elite Controller but not with the long-term nonprogressor status concerning 2DS activating KIRs and HLA-C2 alleles insensitive to miRNA148a regulation. Overall, our findings support a crucial role of NK cells in the control of HIV-1 viremia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / metabolism
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CD4-Positive T-Lymphocytes / virology
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Chromosomes, Human, Pair 19
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Chromosomes, Human, Pair 6
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Disease Progression
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Genetic Predisposition to Disease
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Genotype
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HIV Infections / genetics
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HIV Infections / immunology*
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HIV Infections / metabolism*
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HIV Infections / virology*
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HIV-1 / immunology*
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HLA-C Antigens / genetics
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HLA-C Antigens / immunology*
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Histocompatibility Antigens Class I / genetics
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Histocompatibility Antigens Class I / immunology
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Host-Pathogen Interactions / genetics
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Host-Pathogen Interactions / immunology*
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Humans
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Odds Ratio
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Polymorphism, Genetic
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Receptors, KIR / agonists*
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Receptors, KIR / genetics
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Receptors, KIR / metabolism
Substances
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HLA-C Antigens
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Histocompatibility Antigens Class I
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Receptors, KIR