Post-stroke epilepsy

Tomotaka Tanaka; Masafumi Ihara

doi:10.1016/j.neuint.2017.02.002

Post-stroke epilepsy

Neurochem Int. 2017 Jul:107:219-228. doi: 10.1016/j.neuint.2017.02.002. Epub 2017 Feb 12.

Authors

Tomotaka Tanaka¹, Masafumi Ihara²

Affiliations

¹ Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan. Electronic address: tanakat@hsp.ncvc.go.jp.
² Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan.

PMID: 28202284
DOI: 10.1016/j.neuint.2017.02.002

Abstract

Post-stroke epilepsy (PSE) is a common complication after stroke, yet treatment options remain limited. While many physicians prescribe antiepileptic drugs (AED) for secondary prevention of PSE, it is unclear which treatments are most effective in the prevention of recurrence of symptoms, or whether such therapy is needed for primary prevention. This review discusses the current understanding of epidemiology, diagnoses, mechanisms, risk factors, and treatments of PSE.

Keywords: Blood brain barrier; Early seizure; Epileptogenesis; Late seizure; Post stroke epilepsy; Post stroke seizure.

Publication types

Review

MeSH terms

Animals
Anticonvulsants / pharmacology
Anticonvulsants / therapeutic use
Blood-Brain Barrier / drug effects
Blood-Brain Barrier / metabolism
Blood-Brain Barrier / pathology
Epilepsy / etiology*
Epilepsy / metabolism
Epilepsy / therapy*
Humans
Inflammation Mediators / antagonists & inhibitors
Inflammation Mediators / metabolism
Risk Factors
Stroke / complications*
Stroke / metabolism
Stroke / therapy*

Substances

Anticonvulsants
Inflammation Mediators