Changing Epidemiology of Invasive Mold Infections in Patients Receiving Azole Prophylaxis

Clin Infect Dis. 2017 Jun 1;64(11):1619-1621. doi: 10.1093/cid/cix130.

Abstract

Breakthrough invasive mold infections (IMIs) that occur during posaconazole or voriconazole prophylaxis are rare complications for which epidemiological data are lacking. This retrospective analysis comparing 24 microbiologically documented breakthrough with 66 nonbreakthrough IMIs shows a shift towards non-Aspergillus molds with a significantly increased proportion of rare multidrug-resistant molds.

Keywords: Aspergillus ustus; Scopulariopsis.; antifungal prophylaxis; invasive aspergillosis; mucormycosis.

MeSH terms

  • Adult
  • Antifungal Agents / administration & dosage*
  • Antifungal Agents / pharmacology
  • Aspergillosis / epidemiology
  • Aspergillosis / prevention & control
  • Azoles / administration & dosage*
  • Azoles / pharmacology
  • Drug Resistance, Fungal
  • Female
  • Fungi / drug effects*
  • Fungi / pathogenicity
  • Humans
  • Invasive Fungal Infections / epidemiology*
  • Invasive Fungal Infections / microbiology
  • Invasive Fungal Infections / mortality
  • Invasive Fungal Infections / prevention & control*
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mucormycosis / epidemiology
  • Mucormycosis / prevention & control
  • Retrospective Studies

Substances

  • Antifungal Agents
  • Azoles