Nuclear PKCι-ECT2-Rac1 and Ribosome Biogenesis: A Novel Axis in Lung Tumorigenesis

Martin J Baker; Mariana Cooke; Marcelo G Kazanietz

doi:10.1016/j.ccell.2017.01.008

Nuclear PKCι-ECT2-Rac1 and Ribosome Biogenesis: A Novel Axis in Lung Tumorigenesis

Cancer Cell. 2017 Feb 13;31(2):167-169. doi: 10.1016/j.ccell.2017.01.008.

Authors

Martin J Baker¹, Mariana Cooke¹, Marcelo G Kazanietz²

Affiliations

¹ Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: marcelog@upenn.edu.

PMID: 28196591
DOI: 10.1016/j.ccell.2017.01.008

Abstract

The RhoGEF Ect2 controls cell division and exerts oncogenic functions in multiple cancers. In this issue of Cancer Cell, Justilien et al. report that Ect2 is required for lung tumorigenesis and identified a role for this GEF in ribosomal RNA (rRNA) synthesis that is mediated by Rac1 and PKCι-dependent phosphorylation.

Publication types

Comment

MeSH terms

Carcinogenesis
Cell Line, Tumor
Humans
Isoenzymes / genetics*
Protein Kinase C / genetics*
Ribosomes

Substances

Isoenzymes
Protein Kinase C