Edible solid lipid nanoparticles (SLN) as carrier system for antioxidants of different lipophilicity

PLoS One. 2017 Feb 13;12(2):e0171662. doi: 10.1371/journal.pone.0171662. eCollection 2017.

Abstract

Ferulic acid (FA) and tocopherol (Toc) loaded solid lipid nanoparticles (SLN) were prepared by a hot homogenisation method. The particle size distribution, zeta potential and melting behaviour of the SLN as well as the stability, encapsulation efficiency and radical scavenging activity of FA and Toc in the SLN were analysed. The different formulations containing up to 2.8 mg g-1 of FA or Toc were stable during at least 15 weeks of storage at room temperature. Despite partial degradation and / or release of FA and Toc during storage, significant radical scavenging activity was maintained. DSC measurements and radical scavenging tests after different time periods revealed that the re-structuring of the lipid matrix was connected to the enhanced antioxidant activity of Toc but did not affect the activity of FA.

MeSH terms

  • Antioxidants / administration & dosage*
  • Antioxidants / chemistry
  • Antioxidants / pharmacokinetics
  • Calorimetry, Differential Scanning
  • Coumaric Acids / administration & dosage*
  • Coumaric Acids / chemistry
  • Coumaric Acids / pharmacokinetics
  • Drug Carriers / chemistry
  • Drug Compounding / methods
  • Drug Delivery Systems / methods*
  • Drug Liberation
  • Drug Stability
  • Drug Storage
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacokinetics
  • Humans
  • Lipids / chemistry*
  • Microscopy, Electron, Scanning
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Particle Size
  • Temperature
  • Tocopherols / administration & dosage
  • Tocopherols / chemistry
  • Tocopherols / pharmacokinetics
  • X-Ray Diffraction

Substances

  • Antioxidants
  • Coumaric Acids
  • Drug Carriers
  • Free Radical Scavengers
  • Lipids
  • ferulic acid
  • Tocopherols

Grants and funding

The project was supported by funds of the Federal Ministry of Food and Agriculture (BMEL) based on a decision of the Parliament of the Federal Republic of Germany via the Federal Office for Agriculture and Food (BLE) under the innovation support programme. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.