Suspected X-linked facial dysmorphia and growth retardation in related Labrador retriever puppies

C Dierks; H Hoffmann; F Heinrich; M Hellige; M Hewicker-Trautwein; O Distl

doi:10.1016/j.tvjl.2017.01.004

Suspected X-linked facial dysmorphia and growth retardation in related Labrador retriever puppies

Vet J. 2017 Feb:220:48-50. doi: 10.1016/j.tvjl.2017.01.004. Epub 2017 Jan 4.

Authors

C Dierks¹, H Hoffmann², F Heinrich³, M Hellige⁴, M Hewicker-Trautwein³, O Distl⁵

Affiliations

¹ Institute for Animal Breeding and Genetics, University of Veterinary Medicine, Bünteweg 17p, 30559 Hannover, Germany.
² Department of Pathology, University of Veterinary Medicine, Bünteweg 17, 30559 Hannover, Germany.
³ Kleintierpraxis Neuwarmbüchen, Höfestrasse 22, 30916 Isernhagen, Germany.
⁴ Clinic for Horses, University of Veterinary Medicine, Bünteweg 9, 30559 Hannover, Germany.
⁵ Institute for Animal Breeding and Genetics, University of Veterinary Medicine, Bünteweg 17p, 30559 Hannover, Germany. Electronic address: ottmar.distl@tiho-hannover.de.

PMID: 28190494
DOI: 10.1016/j.tvjl.2017.01.004

Abstract

Seven male Labrador retriever puppies from four different litters were identified with a brachycephalic-like face and skull, associated with low birth weight, severe growth retardation, and reduced abilities to crawl and suckle, which were not compatible with survival. Excessive doming of the cranium, brachygnathia superior and inferior, and an abnormally opened fontanelle were found in all affected puppies by computed tomography and at post-mortem examination. Pedigree analysis supported an X-linked recessive mode of inheritance.

Keywords: Brachycephaly; Congenital malformation; Labrador retriever; X-linked inheritance.

MeSH terms

Animals
Autopsy
Developmental Disabilities / diagnostic imaging*
Dogs / abnormalities*
Face / abnormalities*
Male
Tomography, X-Ray Computed / veterinary