Cancer Bioinformatics for Updating Anticancer Drug Developments and Personalized Therapeutics

Rev Recent Clin Trials. 2017;12(2):101-110. doi: 10.2174/1574887112666170209161444.

Abstract

Background: Last two to three decades, this world witnesses a rapid progress of biomarkers and bioinformatics technologies. Cancer bioinformatics is one of such important omics branches for experimental/clinical studies and applications.

Methods: Same as other biological techniques or systems, bioinformatics techniques will be widely used. But they are presently not omni-potent. Despite great popularity and improvements, cancer bioinformatics has its own limitations and shortcomings at this stage of technical advancements.

Results: This article will offer a panorama of bioinformatics in cancer researches and clinical therapeutic applications-possible advantages and limitations relating to cancer therapeutics. A lot of beneficial capabilities and outcomes have been described. As a result, a successful new era for cancer bioinformatics is waiting for us if we can adhere on scientific studies of cancer bioinformatics in malignant- origin mining, medical verifications and clinical diagnostic applications.

Conclusion: Cancer bioinformatics gave a great significance in disease diagnosis and therapeutic predictions. Many creative ideas and future perspectives are highlighted.

Keywords: Cancer bioinformatics; cancer stem cells; cancer therapy; drug developments; drug response predictions; neoplasm metastasis; personalized cancer therapy.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Biomedical Research / methods
  • Computational Biology / methods*
  • Female
  • Humans
  • Male
  • Molecular Targeted Therapy / methods*
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Precision Medicine / methods*
  • Sensitivity and Specificity

Substances

  • Antineoplastic Agents