Vascular lesions in patient with Takayasu arteritis and massive elevated lipoprotein(a) levels. Residual involvement or premature aterosclerosis?

Abstract

Lipoprotein (a) [Lp(a)] is a lipoprotein defined by presenting a specific apolipoprotein, ApoA, linked to the ApoB-100 by different types of chemical bonds, including a disulfide bridge. Despite their atherogenic mechanism is not fully understood, its importance has been demonstrated in the development of premature aterosclerosis. Multiple studies have shown its role as a cardiovascular risk factor associated with heart disease and stroke. We report the case of a patient with a diagnosis of Takayasu arteritis in which a massive elevation of Lp(a) was detected. We emphasize its diagnostic and therapeutic implications.

Keywords: Ateroesclerosis prematura; Diagnóstico de Takayasu; Lipoprotein; Lipoprotein levels; Lipoproteína; Niveles de lipoproteína; Premature atherosclerosis; Takayasu and ateroesclerosis; Takayasu diagnosis; Takayasu y ateroesclerosis.