A novel Enterovirus 96 circulating in China causes hand, foot, and mouth disease

Virus Genes. 2017 Jun;53(3):352-356. doi: 10.1007/s11262-017-1431-5. Epub 2017 Feb 7.

Abstract

Enterovirus 96 (EV-96) is a recently described member of the species Enterovirus C and is associated with paralysis and myelitis. In this study, using metagenomic sequencing, we identified a new enterovirus 96 strain (EV-96-SZ/GD/CHN/2014) as the sole pathogen causing hand, foot, and mouth disease (HFMD). A genomic comparison showed that EV-96-SZ/GD/CHN/2014 is most similar to the EV-96-05517 strain (85% identity), which has also been detected in Guangdong Province. This is the first time that metagenomic sequencing has been used to identify an EV-96 strain shown to be associated with HFMD.

Keywords: Enterovirus 96; Evolution; Genome sequence; HFMD; Metagenomics.

MeSH terms

  • Child, Preschool
  • China
  • Enterovirus / classification*
  • Enterovirus / genetics
  • Enterovirus / isolation & purification*
  • Enterovirus / pathogenicity
  • Enterovirus C, Human / classification
  • Evolution, Molecular
  • Feces / virology
  • Genome, Viral
  • Genotype
  • Hand, Foot and Mouth Disease / virology*
  • Humans
  • Male
  • Metagenomics
  • Phylogeny
  • RNA, Viral / genetics
  • RNA, Viral / isolation & purification
  • Sequence Analysis
  • Serotyping
  • Whole Genome Sequencing

Substances

  • RNA, Viral