Tailor-made synthesis of fully alkylated/arylated nicotinates by FeCl3-mediated condensation of enamino esters with enones

Sho Hirai; Yurie Horikawa; Haruyasu Asahara; Nagatoshi Nishiwaki

doi:10.1039/c7cc00051k

Tailor-made synthesis of fully alkylated/arylated nicotinates by FeCl₃-mediated condensation of enamino esters with enones

Chem Commun (Camb). 2017 Feb 16;53(15):2390-2393. doi: 10.1039/c7cc00051k.

Authors

Sho Hirai¹, Yurie Horikawa¹, Haruyasu Asahara², Nagatoshi Nishiwaki²

Affiliations

¹ School of Environmental Science and Engineering, Kochi University of Technology, Tosayamada, Kami, Kochi 782-8502, Japan. nishiwaki.nagatoshi@kochi-tech.ac.jp.
² School of Environmental Science and Engineering, Kochi University of Technology, Tosayamada, Kami, Kochi 782-8502, Japan. nishiwaki.nagatoshi@kochi-tech.ac.jp and Research Center for Material Science and Engineering, Kochi University of Technology, Tosayamada, Kami, Kochi 782-8502, Japan.

PMID: 28174763
DOI: 10.1039/c7cc00051k

Abstract

A new method for synthesizing polyalkylated/arylated nicotinates is established using a condensation of enamino esters with enones in the presence of FeCl₃. This method facilitates the introduction of alkyl or aryl groups at any position on demand, which has not been achieved by other procedures.