Epigenomic Inactivation of RasGAPs Activates RAS Signaling in a Subset of Luminal B Breast Cancers

Cancer Discov. 2017 Feb;7(2):131-133. doi: 10.1158/2159-8290.CD-16-1423.

Abstract

Invasion and metastasis of a subset of aggressive luminal B breast cancers is driven by the concomitant inactivation of the RasGAPs DAB2IP and RASAL2. Inactivation of both proteins increases RAS activity and drives invasion, whereas inactivation of DAB2IP specifically promotes NF-κB-mediated epithelial-mesenchymal transition. Cancer Discov; 7(2); 131-3. ©2017 AACRSee related article by Olsen et al., p. 202.

Publication types

  • Comment

MeSH terms

  • Breast Neoplasms*
  • Carrier Proteins
  • Cell Line, Tumor
  • Epigenomics
  • Epithelial-Mesenchymal Transition
  • GTPase-Activating Proteins
  • Humans
  • NF-kappa B
  • ras GTPase-Activating Proteins*

Substances

  • Carrier Proteins
  • DAB2IP protein, human
  • GTPase-Activating Proteins
  • NF-kappa B
  • RASAL2 protein, human
  • ras GTPase-Activating Proteins