Flavonoids from the roots of Artocarpus heterophyllus

Fitoterapia. 2017 Mar:117:133-137. doi: 10.1016/j.fitote.2017.01.016. Epub 2017 Feb 3.

Abstract

Four new flavonoids, artoheteroids A-D (1-4), together with six known ones (5-10), were isolated from the roots of Artocarpus heterophyllus. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR, UV, IR, CD, and HR-ESI-MS. All isolated compounds were screened for their inhibitory abilities against cathepsin K (CatK). Among them, compounds 1-2, 4-6, and 10 were found to have suppression capabilities against CatK with IC50 values ranging from 1.4 to 93.9μM.

Keywords: Artocarpus heterophyllus; Cathepsin K; Isoprenylated flavonoids; Structure elucidation.

MeSH terms

  • Artocarpus / chemistry*
  • Cathepsin K / antagonists & inhibitors*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Flavonoids / chemistry*
  • Flavonoids / isolation & purification
  • Molecular Structure
  • Plant Roots / chemistry*

Substances

  • Enzyme Inhibitors
  • Flavonoids
  • Cathepsin K