Therapeutics for Equine Protozoal Myeloencephalitis

Vet Clin North Am Equine Pract. 2017 Apr;33(1):87-97. doi: 10.1016/j.cveq.2016.12.001. Epub 2017 Feb 1.

Abstract

Equine protozoal myeloencephalitis is an infectious disease of the central nervous system caused by Sarcocystis neurona or Neospora hughesi. Affected horses routinely present with progressive and asymmetrical neurologic deficits. The diagnosis relies on the presence of neurologic signs, ruling out other neurologic disorders, and the detection of intrathecally derived antibodies to either S neurona and/or N hughesi. Recommended treatment is use of an FDA-approved anticoccidial drug formulation. Medical and supportive treatment is provided based on the severity of neurologic deficits and complications. This article focuses on recent data related to diagnosis, pharmacologic treatment, and prevention.

Keywords: Equine protozoal myeloencephalitis (EPM); Neospora hughesi; Prevention; Sarcocystis neurona; Treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Antiprotozoal Agents / therapeutic use*
  • Encephalomyelitis / drug therapy
  • Encephalomyelitis / parasitology
  • Encephalomyelitis / veterinary*
  • Horse Diseases / drug therapy*
  • Horse Diseases / parasitology*
  • Horses
  • Neospora / isolation & purification
  • Sarcocystis / isolation & purification
  • Sarcocystosis / drug therapy
  • Sarcocystosis / parasitology
  • Sarcocystosis / veterinary*

Substances

  • Antiprotozoal Agents