[Glioblastoma, innovations in surgery]

Rev Infirm. 2017 Feb;66(228):31-32. doi: 10.1016/j.revinf.2016.12.008.
[Article in French]

Abstract

One of the innovative principles in glioblastoma surgery consists in making the tumour fluorescent in order for it to be more easily visualised during the procedure. 5-aminolevulinic acid (5-ALA) undergoes an enzyme transformation, turning into another molecule, protoporphyrine IX (PPIX) whose property is fluorescence. It emits red light when it is stimulated by blue light.

Keywords: chirurgie; excision; exérèse; fluorescence; glioblastoma; glioblastome; surgery; traitement; treatment.

MeSH terms

  • Aminolevulinic Acid
  • Brain Neoplasms / nursing
  • Brain Neoplasms / surgery*
  • Glioblastoma / nursing
  • Glioblastoma / surgery*
  • Humans
  • Levulinic Acids / therapeutic use
  • Margins of Excision
  • Neurosurgical Procedures / methods
  • Neurosurgical Procedures / nursing
  • Neurosurgical Procedures / trends*
  • Surgery, Computer-Assisted / methods
  • Surgery, Computer-Assisted / nursing
  • Surgery, Computer-Assisted / trends
  • Therapies, Investigational / nursing
  • Therapies, Investigational / trends

Substances

  • Levulinic Acids