Legionnaire's Disease and Influenza

Eleni E Magira; Sryros Zakynthinos

doi:10.1016/j.idc.2016.10.010

Legionnaire's Disease and Influenza

Infect Dis Clin North Am. 2017 Mar;31(1):137-153. doi: 10.1016/j.idc.2016.10.010.

Authors

Eleni E Magira¹, Sryros Zakynthinos²

Affiliations

¹ 1st Department of Critical Care Medicine, Evangelismos General Hospital, National and Kapodistrian University of Athens, 45-47 Ispilandou Street, Athens 10675, Greece. Electronic address: elmagira@yahoo.com.
² 1st Department of Critical Care and Pulmonary Services, Center of Sleep Disorders, Evangelismos General Hospital, National and Kapodistrian University of Athens, 45-47 Ipsilantou Street, Athens 10676, Greece.

PMID: 28159173
DOI: 10.1016/j.idc.2016.10.010

Abstract

Legionella pneumophila and influenza types A and B viruses can cause either community-acquired pneumonia with respiratory failure, or Legionella infection could attribute to influenza infection with potentially fatal prognosis. Copathogenesis between pandemic influenza and bacteria is characterized by complex interactions between coinfecting pathogens and the host. Understanding the underlying reason of the emersion of the secondary bacterial infection during an influenza infection is challenging. The dual infection has an impact on viral control and may delay viral clearance. Effective vaccines and antiviral therapy are crucial to increase resistance toward influenza, decrease the prevalence of influenza, and possibly interrupt the potential secondary bacterial infections.

Keywords: Coinfection; Host; Immunopathogenesis; Influenza; Legionellosis; Secondary infection.

Publication types

Review

MeSH terms

Coinfection*
Humans
Influenza, Human*
Legionnaires' Disease*
Virulence Factors

Substances

Virulence Factors