A novel liquid crystal spherical microlens array with high optical power and almost 100% of fill-factor is proposed and experimentally demonstrated. The combination of a specific structure and electrical waveforms applied to the electrodes generates an array of spherical microlenses with square aperture. The manufacturing process is simple (patterned electrodes) and the microlenses are reconfigurable by low voltage signals (the electrodes are in contact with the LC layer). This device could be a key for the next generation of autostereoscopic devices based on Integral Imaging technique.