Microwave-Assisted Cascade Strategy for the Synthesis of Indolo[2,3-b]quinolines from 2-(Phenylethynyl)anilines and Aryl Isothiocynates

Wajid Ali; Anjali Dahiya; Ramdhari Pandey; Tipu Alam; Bhisma K Patel

doi:10.1021/acs.joc.6b02912

Microwave-Assisted Cascade Strategy for the Synthesis of Indolo[2,3-b]quinolines from 2-(Phenylethynyl)anilines and Aryl Isothiocynates

J Org Chem. 2017 Feb 17;82(4):2089-2096. doi: 10.1021/acs.joc.6b02912. Epub 2017 Feb 9.

Authors

Wajid Ali¹, Anjali Dahiya¹, Ramdhari Pandey¹, Tipu Alam², Bhisma K Patel¹

Affiliations

¹ Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, India.
² Department of Chemistry, Aligarh Muslim University , Aligarh 202002, India.

PMID: 28155273
DOI: 10.1021/acs.joc.6b02912

Abstract

The in situ generated o-alkynylthioureas obtain by reacting 2-(phenylethynyl)anilines and aryl isothiocynates undergo efficient cascade cyclization in the presence of Ag₂CO₃ to form indoloquinolines under microwave heating. The present tandem process allows the generation of a variety of indolo[2,3-b]quinolines derivatives in good to moderate yields with a wide functional group tolerance.

Publication types

Research Support, Non-U.S. Gov't