Abstract
The stress-related neurohormones including glucocorticoids (GCs) are secreted by hair follicles (HFs), and GCs suppress murine hair growth in vivo. In this study, we found that dexamethasone (Dex), a synthetic GC, increased the expression of dickkopf-1 (DKK1), a known catagen inducer, in dermal papilla (DP) cells, but not in follicular keratinocytes. The neutralizing DKK1 antibody significantly attenuated the Dex-induced inhibition of human hair shaft elongation. In addition, the neutralizing Dkk1 antibody delayed Dex-induced catagen in mice. Collectively, our data strongly suggest that stress-related neurohormones cause DP cells to secrete DKK1, thereby leading to stress-associated disturbances in hair growth.
Keywords:
dermal papilla; dexamethasone; dickkopf 1; hair cycle; hair follicle.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Neutralizing / pharmacology
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Apoptosis / drug effects
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Cell Proliferation / drug effects
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Dexamethasone / pharmacology*
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Female
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Gene Expression / drug effects
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Glucocorticoids / pharmacology*
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Hair / growth & development
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Hair Follicle / cytology
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Hair Follicle / drug effects*
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Hair Follicle / metabolism*
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Humans
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Intercellular Signaling Peptides and Proteins / genetics*
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Intercellular Signaling Peptides and Proteins / immunology
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Intercellular Signaling Peptides and Proteins / metabolism
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Keratinocytes / drug effects
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Keratinocytes / physiology
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Mice
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RNA, Messenger / metabolism
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Receptors, Glucocorticoid / metabolism
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Up-Regulation
Substances
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Antibodies, Neutralizing
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DKK1 protein, human
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Dkk1 protein, mouse
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Glucocorticoids
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Intercellular Signaling Peptides and Proteins
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RNA, Messenger
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Receptors, Glucocorticoid
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Dexamethasone