Human Papillomavirus-Associated Neoplasms of the Head and Neck

Aaron M Udager; Jonathan B McHugh

doi:10.1016/j.path.2016.10.007

Human Papillomavirus-Associated Neoplasms of the Head and Neck

Surg Pathol Clin. 2017 Mar;10(1):35-55. doi: 10.1016/j.path.2016.10.007. Epub 2016 Dec 29.

Authors

Aaron M Udager¹, Jonathan B McHugh²

Affiliations

¹ Department of Pathology, University of Michigan Health System, 2G309 UH, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5054, USA.
² Department of Pathology, University of Michigan Health System, 2G332 UH, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5054, USA. Electronic address: jonamch@umich.edu.

PMID: 28153135
DOI: 10.1016/j.path.2016.10.007

Abstract

Human papillomavirus (HPV) is an essential causal factor in a subset of head and neck neoplasms, most notably oropharyngeal squamous cell carcinoma, for which HPV infection has important diagnostic, prognostic, and therapeutic implications. This article summarizes the current understanding of HPV-associated neoplasms of the head and neck, including the recently described carcinoma with adenoid cystic-like features. Salient clinical, gross, and microscopic features are discussed, and the utility of specific ancillary studies is highlighted.

Keywords: Carcinoma with adenoid cystic-like features; Nasopharyngeal carcinoma; Oropharynx; Sinonasal (Schneiderian) papilloma; Squamous cell carcinoma.

Publication types

Review

MeSH terms

Carcinoma, Adenoid Cystic / diagnosis
Carcinoma, Adenoid Cystic / pathology
Carcinoma, Adenoid Cystic / virology
Carcinoma, Squamous Cell / diagnosis
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / virology
Diagnosis, Differential
Head and Neck Neoplasms / diagnosis
Head and Neck Neoplasms / pathology
Head and Neck Neoplasms / virology*
Humans
Papillomaviridae*
Papillomavirus Infections / complications*
Papillomavirus Infections / diagnosis
Papillomavirus Infections / pathology