Abstract
We are presenting a case of TTP with undetectable levels of ADAMTS 13 in a 39-year-old woman. Diagnosis of systemic lupus was evoked in the setting of thrombotic microangiopathy. The patient presented normal renal function but important neurological impairment. Treatment with daily plasmapheresis as well as Rituximab, cyclophosphamide as steroids was required to achieve clinical improvement.
Keywords:
Lupus; Microangiopathic hemolytic anemia; Thrombotic thrombocytopenic purpura.
MeSH terms
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Adult
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Anemia, Hemolytic / diagnosis*
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Autoantibodies / blood
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Blood Platelets / immunology*
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Codeine / therapeutic use
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Cyclophosphamide / therapeutic use
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Female
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Humans
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Hydroxychloroquine / therapeutic use
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Lupus Erythematosus, Systemic
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Plasmapheresis
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Purpura, Thrombotic Thrombocytopenic / diagnosis*
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Purpura, Thrombotic Thrombocytopenic / immunology
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Remission Induction
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Rituximab / therapeutic use
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Sjogren's Syndrome / drug therapy*
Substances
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Autoantibodies
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Rituximab
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Hydroxychloroquine
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Cyclophosphamide
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Codeine