Interference-Free Surface-Enhanced Raman Scattering Tags for Single-Cell Molecular Imaging with a High Signal-to-Background Ratio

Sisi Ma; Qiang Li; Yongmei Yin; Jie Yang; Dingbin Liu

doi:10.1002/smll.201603340

Interference-Free Surface-Enhanced Raman Scattering Tags for Single-Cell Molecular Imaging with a High Signal-to-Background Ratio

Small. 2017 Apr;13(15). doi: 10.1002/smll.201603340. Epub 2017 Jan 31.

Authors

Sisi Ma¹, Qiang Li¹, Yongmei Yin¹, Jie Yang¹, Dingbin Liu^{1

2}

Affiliations

¹ College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology, and Tianjin Key Laboratory of Molecular Recognition and Biosensing, Nankai University, Tianjin, 300071, China.
² Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, 300071, China.

PMID: 28139881
DOI: 10.1002/smll.201603340

Abstract

An interference-free surface-enhanced Raman scattering tag is constructed to profile the expression of cancer biomarkers at the single-cell level. The Raman tags present a strong and sharp peak in the cellular Raman-silent region, significantly diminishing the background interference. Moreover, the reporters are embedded in the layered gold nanoparticles, avoiding desorption and enzymatic degradation in physiological conditions.

Keywords: SERS nanotags; bioimaging; core-shell nanostructures; gold nanoparticles; nanoprobes.

Publication types

Research Support, Non-U.S. Gov't