A New Way to Beat Intestinal Pathogens

Trends Microbiol. 2017 Mar;25(3):169-170. doi: 10.1016/j.tim.2017.01.003. Epub 2017 Jan 27.

Abstract

In the gastrointestinal tract, the tug of war for iron may provide a new way to vaccinate. Recent work shows that immunizing mice with siderophores (small molecules that microbes produce to capture iron) foils pathogen colonization and may instead allow a commensal to expand.

Publication types

  • Comment

MeSH terms

  • Adjuvants, Immunologic / pharmacology
  • Animals
  • Antibodies / immunology
  • Antibodies / pharmacology*
  • Cholera Toxin / immunology
  • Gastrointestinal Microbiome
  • Gastrointestinal Tract / microbiology
  • Immunization
  • Iron / metabolism*
  • Mice
  • Salmonella / drug effects
  • Salmonella / metabolism*
  • Salmonella Infections / prevention & control*
  • Siderophores / antagonists & inhibitors*
  • Siderophores / immunology*

Substances

  • Adjuvants, Immunologic
  • Antibodies
  • Siderophores
  • Cholera Toxin
  • Iron