Abstract
In the gastrointestinal tract, the tug of war for iron may provide a new way to vaccinate. Recent work shows that immunizing mice with siderophores (small molecules that microbes produce to capture iron) foils pathogen colonization and may instead allow a commensal to expand.
Copyright © 2017 Elsevier Ltd. All rights reserved.
MeSH terms
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Adjuvants, Immunologic / pharmacology
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Animals
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Antibodies / immunology
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Antibodies / pharmacology*
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Cholera Toxin / immunology
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Gastrointestinal Microbiome
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Gastrointestinal Tract / microbiology
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Immunization
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Iron / metabolism*
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Mice
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Salmonella / drug effects
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Salmonella / metabolism*
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Salmonella Infections / prevention & control*
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Siderophores / antagonists & inhibitors*
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Siderophores / immunology*
Substances
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Adjuvants, Immunologic
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Antibodies
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Siderophores
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Cholera Toxin
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Iron