Memory Impairment Following Electroconvulsive Therapy in Chinese Patients with Schizophrenia: Meta-Analysis of Randomized Controlled Trials

Wei Zheng; Guo Tong; Gabor S Ungvari; Chee H Ng; Helen F K Chiu; Ying-Qiang Xiang; Xiao-Lan Cao; Zheng-Rong Liu; Li-Rong Meng; Gábor Gazdag; Yu-Tao Xiang

doi:10.1111/ppc.12206

Memory Impairment Following Electroconvulsive Therapy in Chinese Patients with Schizophrenia: Meta-Analysis of Randomized Controlled Trials

Perspect Psychiatr Care. 2018 Apr;54(2):107-114. doi: 10.1111/ppc.12206. Epub 2017 Jan 30.

Authors

Wei Zheng¹, Guo Tong², Gabor S Ungvari^{3

4}, Chee H Ng⁵, Helen F K Chiu⁶, Ying-Qiang Xiang⁷, Xiao-Lan Cao^{8

9}, Zheng-Rong Liu¹⁰, Li-Rong Meng¹¹, Gábor Gazdag¹², Yu-Tao Xiang¹³

Affiliations

¹ Resident Psychiatrist, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
² Resident Psychiatrist, The National Clinical Research Center for Mental Disorders and Beijing Anding Hospital, Capital Medical University, Beijing, China.
³ Professor, School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia.
⁴ The University of Notre Dame Australia/Marian Centre, Perth, Australia.
⁵ Professor, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
⁶ Professor, Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China.
⁷ Associate Professor, The National Clinical Research Center for Mental Disorders and Beijing Anding Hospital, Capital Medical University, Beijing, China.
⁸ Attending Psychiatrist, Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China.
⁹ Shenzhen Key Laboratory for Psychological Healthcare and Shenzhen Institute of Mental Health, Shenzhen Kangning Hospital and Shenzhen Mental Health Center, Shenzhen, China.
¹⁰ Attending Psychiatrist, Mental Hospital of Guangzhou Civil Administration, Guangzhou, China.
¹¹ Professor, School of Health Sciences, Macao Polytechnic Institute, Macao SAR, China.
¹² Honorary Associate Professor, Consultation-Liaison Psychiatric Service, Szent Istvan and Szent Laszlo Hospitals, Budapest, Hungary.
¹³ Associate Professor, Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China.

PMID: 28138965
DOI: 10.1111/ppc.12206

Abstract

Purpose: To evaluate memory impairment associated with electroconvulsive therapy (ECT)-antipsychotic (AP) combination in comparison to AP monotherapy in schizophrenia.

Design and methods: A systematic literature search of randomized controlled trial (RCTs) was performed.

Findings: Eleven RCTs that compared ECT-AP combination (n = 508) with AP monotherapy (n = 510) were analyzed. ECT-AP combination was associated with greater impairment than AP monotherapy in (1) endpoint memory quotient (MQ) of the Wechsler Memory Scale (WMS)-Revised at the end of the ECT course; and (2) picture recall, counting, recognition, and associative learning of the WMS. However, no group difference was found in MQ at 1 and 2 weeks post-ECT.

Practice implications: The ECT-AP combination was associated with greater transient memory impairment compared to AP monotherapy.

Keywords: ECT-antipsychotic combination; memory impairment; meta-analysis.

Publication types

Meta-Analysis
Review

MeSH terms

China
Electroconvulsive Therapy / adverse effects*
Humans
Memory Disorders / etiology*
Randomized Controlled Trials as Topic*
Schizophrenia / therapy*