Targeted tumor detection: guidelines for developing biotinylated diagnostics

Chem Commun (Camb). 2017 Feb 9;53(13):2154-2157. doi: 10.1039/c7cc00311k.

Abstract

The challenge in achieving precision medicine relies on how to advance and/or enhance new as well as old therapeutic strategies. Here, we highlight the significant role hydrophilicity of biotinylated fluorescent probe's plays on their cellular uptake behaviour.

MeSH terms

  • 1-Naphthylamine / analogs & derivatives
  • 1-Naphthylamine / chemistry
  • 1-Naphthylamine / pharmacokinetics
  • Biotin / analogs & derivatives*
  • Biotin / pharmacokinetics
  • Biotinylation
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / pharmacokinetics
  • HeLa Cells
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Microscopy, Confocal / methods
  • Microscopy, Fluorescence / methods
  • Naphthalimides / chemistry
  • Naphthalimides / pharmacokinetics
  • Neoplasms / diagnostic imaging*
  • Optical Imaging / methods*
  • Quinolones / chemistry
  • Quinolones / pharmacokinetics

Substances

  • Fluorescent Dyes
  • Naphthalimides
  • Quinolones
  • 4-amino-1,8-naphthalimide
  • Biotin
  • 1-Naphthylamine