Data on gut metagenomes of the patients with Helicobacter pylori infection before and after the antibiotic therapy

Oksana E Glushchenko; Andrei E Samoilov; Evgenii I Olekhnovich; Boris A Kovarsky; Alexander V Tyakht; Alexander V Pavlenko; Vlad V Babenko; Andrei K Larin; Elena S Kostryukova; Maja V Malakhova; Elena N Ilina; Rustem A Abdulkhakov; Dilyara I Safina; Tatiana V Grigoryeva; Sayar R Abdulkhakov; Vadim M Govorun

doi:10.1016/j.dib.2017.01.007

Data on gut metagenomes of the patients with Helicobacter pylori infection before and after the antibiotic therapy

Data Brief. 2017 Jan 17:11:68-71. doi: 10.1016/j.dib.2017.01.007. eCollection 2017 Apr.

Authors

Oksana E Glushchenko¹, Andrei E Samoilov², Evgenii I Olekhnovich¹, Boris A Kovarsky¹, Alexander V Tyakht², Alexander V Pavlenko², Vlad V Babenko¹, Andrei K Larin¹, Elena S Kostryukova², Maja V Malakhova¹, Elena N Ilina¹, Rustem A Abdulkhakov³, Dilyara I Safina⁴, Tatiana V Grigoryeva⁴, Sayar R Abdulkhakov⁵, Vadim M Govorun²

Affiliations

¹ Federal Research and Clinical Centre of Physical-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia.
² Federal Research and Clinical Centre of Physical-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia; Moscow Institute of Physics and Technology, Institutskiy per. 9, Dolgoprudny, Moscow Region 141700, Russia.
³ Kazan State Medical University, Butlerova 49, Kazan 420012, Russia.
⁴ Kazan Federal University, Kremlyovskaya 18, Kazan 420008, Russia.
⁵ Kazan State Medical University, Butlerova 49, Kazan 420012, Russia; Kazan Federal University, Kremlyovskaya 18, Kazan 420008, Russia.

Abstract

Antibiotic therapy can lead to the disruption of gut microbiota community with possible negative outcomes for human health. One of the diseases for which the treatment scheme commonly included antibiotic intake is Helicobacter pylori infection. The changes in taxonomic and functional composition of microbiota in patients can be assessed using "shotgun" metagenomic sequencing. Ten stool samples were collected from 4 patients with Helicobacter pylori infection before and directly after the H. pylori eradication course. Additionally, for two of the subjects, the samples were collected 1 month after the end of the treatment. The samples were subject to "shotgun" (whole-genome) metagenomic sequencing using Illumina HiSeq platform. The reads are deposited in the ENA (project ID: PRJEB18265).

Keywords: Antibiotic therapy; Gut microbiota; Helicobacter pylori; Metagenome.