Two new flavans from the roots of Dianella ensifolia (L.) DC

Nat Prod Res. 2017 Jul;31(13):1561-1565. doi: 10.1080/14786419.2017.1283501. Epub 2017 Jan 30.

Abstract

Two new flavans, named (2S)-2',4'-dihydroxy-7-methoxy-8-methylflavan (1) and (2S)-2'-hydroxy-4',7-dimethoxy-8-methylflavan (2) were isolated from the roots of Dianella ensifolia. Their structures were elucidated by extensive spectroscopic measurements and comparison with data reported in literatures. Compounds 1 and 2 displayed cytotoxic effects against cancer cell lines MDA-MB-231, B16-F10, HCT116 and A549.

Keywords: Dianella ensifolia; cytotoxicity; flavans.

MeSH terms

  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Cell Death / drug effects
  • Cell Line, Tumor
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology*
  • Humans
  • Magnoliopsida / chemistry*
  • Molecular Structure
  • Plant Roots / chemistry*

Substances

  • Antineoplastic Agents
  • Flavonoids