Click and Release: SO2 Prodrugs with Tunable Release Rates

Xingyue Ji; Eman M El-Labbad; Kaili Ji; Deena S Lasheen; Rabah A T Serya; Khaled A Abouzid; Binghe Wang

doi:10.1021/acs.orglett.6b03805

Click and Release: SO₂ Prodrugs with Tunable Release Rates

Org Lett. 2017 Feb 17;19(4):818-821. doi: 10.1021/acs.orglett.6b03805. Epub 2017 Jan 30.

Authors

Xingyue Ji¹, Eman M El-Labbad², Kaili Ji¹, Deena S Lasheen², Rabah A T Serya², Khaled A Abouzid², Binghe Wang¹

Affiliations

¹ Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University , Atlanta, Georgia 30303 United States.
² Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University , Abbassia, Cairo 11566, Egypt.

PMID: 28133965
DOI: 10.1021/acs.orglett.6b03805

Abstract

Employing an intramolecular cycloaddition reaction, we have developed a series of SO₂ prodrugs with tunable release rates with half-lives ranging from minutes to days.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Click Chemistry
Cycloaddition Reaction
Drug Design
Drug Liberation
Half-Life
Hydrophobic and Hydrophilic Interactions
Kinetics
Mice
Molecular Structure
Prodrugs / chemistry*
Prodrugs / metabolism*
RAW 264.7 Cells
Structure-Activity Relationship
Sulfur Dioxide / chemistry*
Sulfur Dioxide / metabolism*

Substances

Prodrugs
Sulfur Dioxide